Anti-Zap-70 (Ab-493) Antibody

From Antibodies.com, this rabbit polyclonal reagent is raised against an epitope mapping to a region surrounding residue 493 of human Zap-70 and detects the Zeta-chain-associated protein kinase 70 in human, mouse, and rat samples. Zap-70 is a 70 kDa cytoplasmic tyrosine kinase that couples T-cell receptor engagement to downstream signaling cascades, positioning it as a key marker in studies of lymphocyte activation, thymic selection, and primary immunodeficiency research. The unconjugated preparation is supplied as 100 µl of antiserum and is validated for western blot and immunohistochemistry workflows, supporting applications in immunology, signal transduction, and onco-hematology where aberrant Zap-70 expression has been documented in chronic lymphocytic leukemia. Refrigerate the vial between uses to preserve reagent activity, and aliquot if repeated freeze-thaw cycles are anticipated.