Anti-YARS2 Antibody

The YARS2 gene encodes mitochondrial tyrosyl-tRNA synthetase, the enzyme that charges tRNA^Tyr with tyrosine inside the mitochondrial matrix and supports translation of the 13 mtDNA-encoded subunits of the oxidative phosphorylation machinery. This unconjugated rabbit IgG polyclonal reagent from Antibodies.com is raised against YARS2 and is supplied as 200 µl of liquid antiserum for researchers investigating mitochondrial translation, respiratory chain assembly, or rare mitochondrial disease models such as MLASA2 (mitochondrial myopathy, lactic acidosis, and sideroblastic anemia type 2), in which biallelic YARS2 variants have been reported.

Validated uses include Western blot detection of the endogenous human protein in cell and tissue lysates, and immunohistochemistry on fixed sections to map YARS2 expression across tissues. The antibody reacts with human YARS2 and is provided unconjugated so it can be paired with secondary reagents of the researcher's choice (HRP, fluorophore, or biotin) for chemiluminescent, fluorescent, or chromogenic readouts. For handling, refrigerate on arrival, aliquot to limit freeze-thaw cycles, and protect from light.