Anti-XRN1 Antibody

Raised in rabbit against the human 5'-3' exoribonuclease XRN1, this unconjugated polyclonal IgG antibody from Antibodies.com is supplied as 100 µl of ready-to-use reagent for western blot detection of endogenous XRN1 protein. XRN1 is a major cytoplasmic effector of mRNA turnover, nonsense-mediated decay, and stress granule assembly, making this reagent useful for studies of post-transcriptional gene regulation, processing body dynamics, and viral restriction pathways. The polyclonal format increases the likelihood of recognizing multiple epitopes on the ~194 kDa target, supporting consistent immunoblot signal when probing whole-cell or cytoplasmic extracts from human cell lines and primary tissue. Investigators can use the antibody to monitor XRN1 expression, subcellular localization, and recruitment to stress granules under basal and challenged conditions, including translational arrest and oxidative stress. Refrigerate the vial upon arrival and avoid repeated freeze-thaw cycles to preserve activity; aliquot small working volumes for long-term use. Provided for research use only as a single-use vial, the reagent is intended for immunoblotting applications and is not validated for diagnostic use.