Anti-XRCC3 Antibody

The XRCC3 protein operates within the homologous recombination DNA repair pathway, where it cooperates with RAD51C and other RAD51 paralogs to resolve double-strand breaks and preserve chromosomal integrity. This unconjugated rabbit polyclonal reagent from Antibodies.com is validated for western blot, immunohistochemistry, and immunofluorescence workflows across human and mouse sample types, offering laboratories focused on DNA damage response, cancer biology, and radiosensitivity research a versatile detection tool.

Supplied as a 100 µl aliquot in a single-use vial at 1 mg/ml, the antibody is buffered in PBS containing 0.1% sodium azide and 50% glycerol, a cryoprotectant combination that minimises freeze-thaw damage and supports storage at -20 °C. The polyclonal format recognises multiple epitopes across the XRCC3 primary sequence, often producing stronger signals than monoclonal alternatives in immunohistochemistry, where formalin-mediated epitope masking is a known concern.

XRCC3 expression is frequently dysregulated in tumours with defective homologous recombination, making this reagent useful for research on BRCA-associated cancers, Fanconi anaemia pathway studies, and mechanistic investigations into PARP inhibitor sensitivity. Each batch is produced under the Antibodies.com antibody production programme to deliver consistent band patterns in WB, defined nuclear localisation in IF, and specific labelling in IHC tissue sections.