Anti-XRCC1 Antibody

XRCC1 (X-Ray Repair Cross Complementing 1) is a ~69 kDa scaffold protein essential for DNA single-strand break repair and the base excision repair pathway, where it coordinates DNA ligase III, DNA polymerase beta, and PARP recruitment to damage sites. This unconjugated rabbit polyclonal antibody from Antibodies.com is raised against XRCC1 and validated for Western blot (WB) and immunohistochemistry (IHC) applications. The reagent cross-reacts with Human, Mouse, and Rat samples, supporting comparative studies in cell culture and tissue-based research models of genomic instability, cancer biology, and DNA damage response. Provided as a 100 µl aliquot of polyclonal antiserum, it is suitable for chromogenic and fluorescent detection workflows because it binds XRCC1 without a conjugated reporter, allowing users to pair it with their preferred secondary antibody. The antibody is suited for studies of PARP-mediated repair, chemotherapy resistance mechanisms, and oxidative lesion processing in research use only settings.