Anti-XPNPEP3 Antibody

The Antibodies.com polyclonal antiserum is raised in rabbits against human XPNPEP3 and supplied as an unconjugated reagent in a 100 µL vial. XPNPEP3 encodes an N-terminal X-prolyl aminopeptidase that localizes to the mitochondrial matrix, where it contributes to the maturation of mitochondrial proteins by removing N-terminal residues adjacent to proline. The antibody was validated for Western blot and immunofluorescence workflows on human samples, supporting detection of endogenous XPNPEP3 in cultured cell lines and primary tissue. Researchers studying mitochondrial aminopeptidase function, ciliopathy-associated pathways, or the rare nephronophthisis-like nephropathy linked to loss-of-function variants in XPNPEP3 can use this reagent to confirm expression, subcellular localization, and perturbation effects following siRNA knockdown or CRISPR editing. The polyclonal format increases the likelihood of recognition across multiple epitopes, which is useful when probing truncated isoforms or patient-derived mutants. For long-term stability, store the vial refrigerated and protect from light; aliquoting on first use is recommended to limit freeze-thaw cycles. Each lot is produced under standard quality control at Antibodies.com and is intended for research use only in vitro applications.