Anti-XIAP Antibody

XIAP (X-linked Inhibitor of Apoptosis) is a key regulator of programmed cell death, binding and neutralizing active caspases to suppress apoptotic signaling cascades. This rabbit polyclonal antibody from Antibodies.com was raised against XIAP and is validated for western blot, immunohistochemistry, and ELISA workflows across human, mouse, and rat samples, supporting comparative apoptosis research, tumor biology investigations, and studies of chemoresistance mechanisms in cancer cell models.

The unconjugated format provides flexibility to pair the primary reagent with HRP-, biotin-, or fluorophore-conjugated secondary antibodies selected by the researcher. Supplied as 100 µl of polyclonal antiserum, the antibody supports multiple staining or blotting rounds and can be aliquoted at the bench to limit repeated freeze-thaw exposure. Store refrigerated and protect from light to maintain long-term activity, with single-use working aliquots drawn for active experiments.

XIAP overexpression has been documented in hepatocellular carcinoma, prostate cancer, leukemia, and several solid tumor lineages, where elevated levels correlate with poor therapeutic response and resistance to chemotherapy-induced apoptosis. Researchers investigating IAP family function, caspase-3 and caspase-9 modulation, or survival pathway cross-talk use this reagent to probe endogenous protein levels, assess treatment-induced changes, and characterize pathway activity in primary tissues and cultured cells.