Anti-WWOX Antibody

A rabbit polyclonal reagent from Antibodies.com, this Anti-WWOX Antibody targets WW domain-containing oxidoreductase, a tumor suppressor protein studied extensively in oncology, apoptosis, and metabolic disease research. Supplied as 100 µl of unconjugated antiserum, the reagent cross-reacts with both human and mouse WWOX, supporting comparative studies between species in translational workflows.

Validated for Western blot and immunohistochemistry, the polyclonal antibody binds multiple epitopes on the WWOX protein, enhancing detection sensitivity in tissue sections and whole-cell lysate preparations. Researchers investigating chromosomal alterations at the FRA16D fragile site, where WWOX is encoded at 16q23.3-24.1, can apply this reagent to track expression changes linked to tumor progression pathways and stress-response signaling.

Beyond cancer biology, WWOX plays documented roles in steroid metabolism, bone homeostasis, and neuronal survival, extending this antibody's utility to studies of neurodegenerative disease mechanisms, hormone-driven signaling cascades, and fragile-site genomic instability. Storage at refrigerated temperatures preserves activity through extended use, and the unconjugated format allows flexible pairing with custom reporter conjugates for multiplex imaging.