Anti-WRB Antibody

This rabbit polyclonal primary antibody recognizes WRB, a tail-anchored membrane protein that functions as a receptor component in the guided entry of tail-anchored protein pathway at the endoplasmic reticulum. The Antibodies.com reagent is supplied as 50 µl of unconjugated rabbit IgG antiserum for Western blot and immunohistochemistry. Its reactivity with human, mouse, and rat samples supports comparative studies of ER protein insertion, intracellular trafficking, and WRB expression across mammalian models.

Western blot workflows can use the antibody to examine endogenous WRB in whole-cell or tissue lysates, while immunohistochemistry can reveal its distribution in tissue sections. Because the antibody is unconjugated, researchers can select an HRP- or fluorophore-conjugated secondary antibody suited to their detection system. WRB has also been linked to autosomal recessive non-syndromic hearing loss, so the reagent is relevant to expression and localization studies using hearing-loss models. For research use only, store at -20 °C and aliquot after the first thaw to limit repeated freeze-thaw cycles.