Anti-WNK1 Antibody

WNK1 (WNK Lysine Deficient Protein Kinase 1) is a serine-threonine kinase central to electrolyte balance, ion transport regulation, and blood pressure homeostasis, making it a frequent target in renal and cardiovascular research. This unconjugated rabbit polyclonal reagent from Antibodies.com is supplied at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, shipped as a 100 µl aliquot that supports multiple experimental runs. The antibody is validated for Western blot, immunohistochemistry, and immunofluorescence workflows, and it reacts with Human, Mouse, and Rat samples, allowing comparative studies across standard model organisms.

Because WNK1 activity modulates the SPAK and OSR1 signaling axis and downstream NCC and NKCC1 transporters, researchers apply this reagent to investigate signaling mechanisms in kidney epithelial cells, neuronal tissue, and cardiovascular models. The polyclonal format offers broader epitope coverage for detecting full-length WNK1 and its isoforms, and the glycerol-containing buffer supports storage at -20 degrees C with minimal freeze-thaw cycling. Aliquot upon arrival to preserve activity across long projects, and the sodium azide preservative allows routine handling on the bench without immediate refrigeration between uses.