Anti-WHSC1L1 Antibody

WHSC1L1, also known as NSD3, is a SET-domain histone methyltransferase that catalyzes methylation of histone H3 at lysine 36 and is implicated in chromatin regulation, transcription elongation, and oncogenic signaling across several tumor types. The locus at 8p11.23 is recurrently amplified in breast carcinoma, and NUP98-NSD3 fusions have been reported in certain myeloid leukemias, motivating continued interest in tools that detect this protein.

For researchers studying this target, Antibodies.com supplies a 100 µl aliquot of unconjugated rabbit polyclonal antibody raised against WHSC1L1, validated for Western blot, immunohistochemistry, and immunofluorescence workflows. Reactivity has been confirmed against human and mouse samples, supporting cross-species studies in cell lines and primary tissue.

The polyclonal format delivers recognition of multiple epitopes across the target, useful when probing full-length WHSC1L1 alongside the shorter NSD3-short isoform that arises from an internal translation start site. As an unconjugated primary, it can be paired with HRP-, fluorophore-, or biotin-labeled secondary reagents chosen by the user, giving flexibility for chromogenic, fluorescent, or proximity-based detection platforms.

For storage, refrigerate short-term; for longer-term storage, aliquot and freeze to preserve activity and minimize freeze-thaw cycles. This product is supplied by Antibodies.com for research use only.