Anti-WFS1 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com specifically targets WFS1 (Wolframin), a transmembrane endoplasmic reticulum protein whose loss-of-function mutations underlie Wolfram syndrome, a rare autosomal recessive disorder featuring diabetes insipidus, diabetes mellitus, optic atrophy, and deafness. The antibody is validated for Western blot detection in human, mouse, and rat samples and is used by researchers investigating ER calcium homeostasis, unfolded protein response signaling, pancreatic beta-cell biology, and neurodegeneration pathways. Supplied as 100 µl at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the formulation offers cryoprotection for low-temperature storage with minimal freeze-thaw damage when aliquoted into single-use portions. Polyclonal reactivity enables broader epitope recognition for detecting endogenous WFS1 expression across whole-cell lysates and membrane-enriched tissue fractions, supporting studies of optic nerve pathology, auditory function, and metabolic disease models.