Anti-WDR77 Antibody

This polyclonal antibody targets WDR77, a core scaffold subunit of the PRMT5 methylosome complex also referenced in the literature as MEP50 or p44. The unconjugated reagent is raised in rabbit and detects the endogenous human protein in western blot, immunohistochemistry, and immunofluorescence workflows, supporting studies of symmetric arginine dimethylation, spliceosome assembly, and chromatin-associated signaling where WDR77 partners with PRMT5 to modify histone and Sm substrates.

The reagent is supplied as 100 µl of liquid at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, a formulation that helps protect the protein from repeated freeze-thaw cycling during storage. Researchers pair this antibody with nuclear counterstains in immunofluorescence to localize WDR77 to nuclear speckles, or apply it in IHC of prostate and lung tissue sections where WDR77 overexpression has been linked to tumor progression in published studies.

Manufactured by Antibodies.com as part of its primary antibody range, the reagent is reactive with human samples and serves investigators working on RNA processing, transcriptional regulation, spliceosome biogenesis, and cancer biology applications.