Anti-WDR5 Antibody

The WDR5 (WD Repeat Domain 5) protein functions as a conserved scaffold subunit of MLL/SET1 histone methyltransferase complexes, where it supports H3K4 methylation and chromatin-mediated transcriptional control. Antibodies.com offers this unconjugated rabbit polyclonal reagent for detecting endogenous WDR5 in validated Western blot (WB) and immunohistochemistry (IHC) workflows. Cross-reactivity has been confirmed against human, mouse, and rat samples, supporting translational studies and comparative work across model organisms and primary tissue specimens.

Each vial contains 100 µl of polyclonal antiserum in a liquid format compatible with standard laboratory protocols. WDR5 participates in ribosome biogenesis, embryonic stem cell self-renewal, and leukemogenic MLL fusion complexes, making it a frequent target in studies of mixed lineage leukemia, epigenetic regulation, and cancer cell proliferation. Researchers apply the antibody to assess expression levels, monitor complex assembly, and track post-translational regulation of WDR5 across diverse cellular contexts.