Anti-WDR5 Antibody

The WDR5 protein (WD repeat-containing protein 5) acts as a core scaffolding component of the MLL/SET1 histone H3 lysine 4 methyltransferase complex and is required for normal H3K4 methylation at active gene promoters. This rabbit polyclonal reagent from Antibodies.com was raised against recombinant WDR5 and is supplied as 100 µl of unconjugated antiserum, validated for western blot and immunohistochemistry on human, mouse, and rat tissue samples. Polyclonal recognition across multiple WDR5 epitopes allows sensitive detection of endogenous protein in chromatin-associated nuclear fractions, and the unconjugated format permits flexible downstream labelling with HRP, fluorophore, or biotin conjugates. The reagent supports research into transcriptional regulation, embryonic development, and the link between WDR5 overexpression and leukaemia, where it is now pursued as a small-molecule drug-discovery target.