Anti-WDR4 Antibody

This unconjugated rabbit polyclonal reagent from Antibodies.com targets WDR4, a WD-repeat protein acting as a core component of the tRNA(m7G46) methyltransferase complex that installs m7G modifications on tRNAs and supports translation efficiency. Supplied as a 100 µl aliquot in a vial, the antibody has been validated for western blot and immunohistochemistry workflows and reacts with human and mouse samples. The WDR4 protein has attracted interest in studies of primordial dwarfism, microcephaly, and Galloway-Mowat syndrome, where loss-of-function variants disrupt tRNA methylation, impair ribosome function, and compromise cell growth and neural development, making it a useful marker for research into translation control and tissue patterning. As a polyclonal reagent, the antibody recognizes multiple epitopes across the WDR4 sequence, supporting detection in whole-cell lysates, paraffin-embedded tissue sections, and other fixed samples used in bench research.