Anti-WBSCR22 Antibody

The rabbit polyclonal reagent supplied by Antibodies.com targets the WBSCR22 methyltransferase, a ribosome biogenesis factor mapped to the Williams-Beuren syndrome critical region on chromosome 7q11.23 and also known as MERM1. WBSCR22 catalyzes 2'-O-methylation of 18S rRNA during early ribosome assembly, and altered expression has been linked to ribosomal stress and to transcriptional dysregulation associated with the hemizygous 7q11.23 deletion. Raised in rabbit and supplied as an unconjugated polyclonal preparation, the antibody recognizes the human WBSCR22 protein in Western blot and immunohistochemistry workflows.

Investigators studying rRNA modification, ribosome assembly, or the cellular consequences of the Williams-Beuren deletion interval use this reagent to probe WBSCR22 expression in cultured human cell lines and in tissue sections. Each vial delivers 100 µL of antibody, intended for research use only, and is suited to standard immunoblotting of whole-cell lysates as well as chromogenic or fluorescent IHC on formalin-fixed paraffin-embedded specimens. Storage at -20 °C in single-use aliquots helps preserve activity across multiple freeze-thaw cycles, and the polyclonal format provides multiple epitope recognition for detection of endogenous WBSCR22 in human samples.