Anti-VPAC1 Antibody

The VPAC1 receptor, also known as vasoactive intestinal peptide receptor 1 (VIPR1), is a class B G protein-coupled receptor that binds the neuropeptides VIP and PACAP with high affinity and signals through Gs proteins to elevate cAMP and mobilize intracellular calcium. Antibodies.com supplies a rabbit polyclonal antibody raised against this receptor for research on neuropeptide biology, immune cell regulation, and GPCR-mediated signal transduction in human tissue.

This unconjugated reagent is validated for Western blot and ELISA workflows on human samples. Supplied as 100 µl in a single vial, the antibody gives researchers the flexibility to conjugate to enzymes, fluorophores, or biotin as required by individual assay designs. Because it is polyclonal, the reagent recognizes multiple epitopes on VPAC1, supporting broader recognition across native and denatured protein preparations derived from cell culture lysates and tissue homogenates.

For storage, the vial should be refrigerated and protected from light, with aliquots drawn on first use to limit freeze-thaw cycles and preserve reagent activity. Investigators have applied this antibody to studies of VPAC1 expression in airway epithelium, lymphocytes, and neuronal tissue where VIP and PACAP signaling influence cAMP-dependent transcription, calcium mobilization, and receptor desensitization dynamics.