Anti-VEGFR2 (Ab-951) Antibody

This polyclonal reagent from Antibodies.com specifically recognizes VEGFR2 (vascular endothelial growth factor receptor 2, also called KDR or Flk-1) when phosphorylated at tyrosine 951, an autophosphorylation site that couples ligand-driven receptor activation to downstream control of endothelial cell migration and vascular permeability. Raised in rabbit and supplied as an unconjugated antibody in a 100 µl volume, it is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human specimens.

Because the epitope maps to the phospho-Tyr951 motif rather than to total VEGFR2 protein, the antibody is well suited to stimulation and time-course studies that distinguish VEGF-induced VEGFR2 phosphorylation from baseline receptor expression. Researchers investigating tumor angiogenesis, retinal neovascularization, and VEGF-pathway inhibitor pharmacology commonly combine phospho-Y951 VEGFR2 detection with total VEGFR2 blots to resolve pathway activation kinetics in cultured endothelial cells and in tissue sections, supporting basic vascular biology research and preclinical drug-response profiling. For research use only.