Anti-VEGF-A (R159) Antibody

VEGF-A, or Vascular Endothelial Growth Factor A, drives angiogenesis and vascular permeability in tissues, and is a central target in tumor biology, retinal disease, and wound healing research. This unconjugated rabbit polyclonal reagent from Antibodies.com recognizes an epitope around the R159 region of human VEGF-A, a residue located within the receptor-binding interface that influences KDR/Flk-1 and Flt-1 engagement.

Validated for immunohistochemistry (IHC), the antibody cross-reacts with mouse and rat VEGF-A in addition to the human protein, supporting comparative work across rodent disease models and human tissue specimens. It is supplied at 1 mg/ml in phosphate buffered saline (PBS) containing 0.05% sodium azide at approximately pH 7.2, packaged as a 50 µl vial providing enough volume for multiple staining runs. The sodium azide preservative means standard cold-chain handling applies, and aliquoting upon first use helps preserve activity across repeated experiments.

Researchers apply this reagent to tumor angiogenesis studies, diabetic retinopathy models, and investigations of VEGF expression in inflammatory and ischemic tissue contexts. Refrigerated storage is recommended for this liquid polyclonal preparation, and the unconjugated format allows users to pair it with their preferred HRP-, biotin-, or fluorophore-conjugated secondary detection systems.