Anti-VDAC1 Antibody

The polyclonal primary antibody from Antibodies.com is raised in rabbit and targets VDAC1 (Voltage-Dependent Anion Channel 1), the most abundant integral channel of the outer mitochondrial membrane. This unconjugated reagent is supplied at 100 µl volume and is validated for Western blot and immunohistochemistry workflows on human samples.

VDAC1 functions as a major conduit for metabolites, ions, and small molecules crossing the mitochondrial outer membrane, and participates in apoptosis regulation through interactions with Bcl-2 family proteins and cytosolic hexokinase. The protein resolves at approximately 31 kDa by SDS-PAGE, making it readily detectable in whole-cell and mitochondrial lysate preparations. Researchers working in cancer metabolism, neurodegeneration, ischemia-reperfusion injury, and mitochondrial permeability transition rely on this reagent to probe outer-membrane integrity and channel biology.

For optimal preservation, store refrigerated and protect from light; small-volume aliquots help maintain titre across multiple experiments and limit freeze-thaw damage. Provided as a research-use-only reagent from Antibodies.com.