Anti-VCP (p97) Antibody

VCP, also known as p97 or Cdc48, is a ubiquitously expressed AAA+ ATPase that drives protein extraction, unfolding, and translocation through the ubiquitin-proteasome system and endoplasmic-reticulum-associated degradation (ERAD) pathway. Mutations in the VCP gene cause multisystem proteinopathy, a rare adult-onset disorder combining inclusion body myopathy, Paget's disease of bone, frontotemporal dementia, and amyotrophic lateral sclerosis, making the protein a central focus of neurodegeneration and muscle-biology research.

This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against VCP and validated for Western blot, immunohistochemistry, and immunofluorescence workflows on human samples. Supplied as 100 µL of polyclonal antiserum, the antibody recognizes an epitope on the p97 protein and supports detection of endogenous VCP in cell lysates, fixed tissue sections, and cultured cells. Investigators studying proteostasis, ER stress response, mitochondrial quality control, and aggregate clearance rely on this reagent to probe VCP expression, post-translational modification, and subcellular localization in disease models and patient-derived specimens.