Anti-VCP Antibody

Valosin-containing protein (VCP), also known as p97, is a conserved AAA+ ATPase central to protein quality control, ER-associated degradation, and the ubiquitin-proteasome pathway. This unconjugated rabbit polyclonal reagent from Antibodies.com is raised against VCP and supports detection across multiple experimental platforms. Researchers apply it in western blot workflows to assess VCP expression and aggregation status in cell lysates, in immunohistochemistry to localize distribution in fixed tissue sections, and in ELISA-based quantitation. The antibody recognizes the human, mouse, and rat orthologs, enabling cross-species comparison in models of neurodegeneration, inclusion body myopathy with Paget disease and frontotemporal dementia, and cancer biology where VCP dysfunction is implicated.

Supplied as 100 µl of polyclonal antiserum, the reagent is unconjugated to allow flexible pairing with secondary labels such as HRP, biotin, or fluorophores depending on the chosen assay. Storage at -20 °C in single-use aliquots preserves activity across repeated freeze-thaw cycles, and the polyclonal nature broadens epitope coverage for isoforms and post-translational modifications. The product ships as a single vial ready for dilution into standard blocking buffers.