Anti-VCAM1 Antibody [Assigned #A11236]

This unconjugated rabbit monoclonal IgG reagent from Antibodies.com targets Vascular Cell Adhesion Molecule 1 (VCAM1, also called CD106), an immunoglobulin-like transmembrane sialoglycoprotein expressed on activated endothelial cells where it mediates adhesion of circulating leukocytes including lymphocytes, monocytes, eosinophils, and basophils. The 50 µl liquid aliquot is supplied in a single-use vial and has been validated for Western blot, immunohistochemistry, immunofluorescence, and immunoprecipitation workflows.

Cross-reactivity is confirmed for Human, Mouse, and Rat samples, making the reagent a practical option for comparative studies of vascular inflammation, endothelial dysfunction, and atherosclerosis. The unconjugated format provides flexibility for downstream labeling with HRP, biotin, or fluorophore conjugates, and the rabbit IgG isotype pairs with standard anti-rabbit secondary reagents used in routine immunodetection. As a monoclonal reagent, the antibody offers consistent lot-to-lot staining performance across both denaturing and native preparations.

Beyond its role in leukocyte recruitment and rolling, VCAM1 is widely investigated as an inflammatory biomarker in models of atherogenesis, vascular injury, ischemia-reperfusion, and diabetes-related endothelial damage. Researchers tracking VCAM1 expression on tissue sections, isolated endothelial cells, or whole-cell lysates can apply this reagent to studies of vascular pathology, plaque biology, and drug-response assessment.