Anti-VAV1 Antibody

VAV1 is a hematopoietic lineage-restricted guanine nucleotide exchange factor for Rho family GTPases, transducing signals from antigen and cytokine receptors into cytoskeletal reorganization, transcriptional activation, and proliferation in lymphocytes. This rabbit polyclonal antibody from Antibodies.com is raised against VAV1 and affinity-purified to recognize the endogenous human protein in both denatured and native preparations.

Validated for Western blot and immunohistochemistry, the unconjugated format permits use with the user's preferred secondary detection reagents and chromogens. Each vial delivers 100 µl of antibody, sufficient for multiple immunoblots or tissue sections depending on working dilution.

Investigators studying T-cell receptor signaling, B-cell maturation, leukocyte cytoskeletal dynamics, and VAV1's role as a proto-oncogene in hematopoietic malignancies use this reagent to assess expression levels, phosphorylation status, and tissue distribution in lymphoid samples, immune cell lysates, and relevant tumor models.

For long-term integrity, aliquot upon first thaw and store at -20°C; avoid repeated freeze-thaw cycles to preserve binding activity. Working dilutions should be titrated empirically against the chosen detection system and sample type.