Anti-VASP (phospho S157) Antibody

This rabbit polyclonal antibody from Antibodies.com selectively recognizes VASP (vasodilator-stimulated phosphoprotein) when phosphorylated at serine 157, a regulatory site controlled by cAMP- and cGMP-dependent protein kinases (PKA and PKG). The phospho-S157 modification modulates VASP's interaction with filamentous actin and its anti-capping activity at growing filament termini, making this reagent a sensitive marker for studying cyclic-nucleotide signaling in cell lysates and tissue sections.

Supplied as 100 µl of unconjugated rabbit IgG in a single vial, the antibody is validated for western blot and immunohistochemistry and has been confirmed to react with human, mouse, and rat VASP. Investigators working on endothelial nitric oxide signaling, platelet activation, smooth-muscle contractility, and cytoskeletal remodeling routinely monitor phospho-S157 VASP as a downstream readout of cAMP/PKA and cGMP/PKG pathway activity.