Anti-VAPB Antibody

The VAPB protein (Vesicle-Associated Membrane Protein-Associated Protein B/C) is an evolutionarily conserved endoplasmic reticulum resident that participates in vesicle trafficking, unfolded protein response signaling, and lipid exchange at membrane contact sites. This rabbit polyclonal antibody, distributed by Antibodies.com, is raised against human VAPB and validated for Western blot, immunohistochemistry, and immunofluorescence workflows. Supplied as 100 µl of unconjugated antisera, the reagent can be paired with secondary antibodies of choice for chromogenic or fluorescence detection. Laboratories investigating motor neuron biology apply VAPB reagents to study the P56S mutation linked to familial amyotrophic lateral sclerosis type 8, as well as VAPB's broader roles in ER stress, the secretory pathway, and inter-organelle membrane contact site dynamics. The polyclonal format broadens recognition across multiple epitopes of the target, supporting reproducible signal in tissue sections and cell preparations alike.