Anti-USP7 (C-terminus) Antibody

This unconjugated mouse monoclonal antibody from Antibodies.com targets the C-terminus of USP7 (Ubiquitin-Specific Protease 7, also known as HAUSP), a deubiquitinating enzyme that regulates DNA damage response, p53 and MDM2 turnover, and cell cycle progression. The reagent is supplied as 100 µl of purified immunoglobulin in a buffer containing 0.1M Tris-Glycine at pH 7.4 with 150 mM NaCl, 0.2% sodium azide as preservative, and 50% glycerol to limit freeze-thaw damage during routine handling. It is validated for Western blot (WB) and immunocytochemistry (ICC) on human samples, where the C-terminal epitope lets researchers track full-length endogenous USP7 without competing with binders that recognize the N-terminal TRAF-like domain.

Because USP7 sits at the intersection of ubiquitin biology, oncology, and DNA repair research, this clone supports cell-based and biochemical workflows that examine HAUSP expression, subcellular localization, and engagement with substrates such as MDM2 and p53. The monoclonal format delivers lot-to-lot consistency across replicate experiments, and the unconjugated presentation allows users to pair the antibody with HRP, biotin, or fluorophore-conjugated secondary reagents of their choosing. The 100 µl vial is sized for routine blotting and imaging campaigns in academic and translational laboratories working on deubiquitinase signaling pathways.