Anti-USP44 Antibody

Raised in rabbit against the human USP44 deubiquitinase, this unconjugated polyclonal reagent from Antibodies.com is supplied as 100 µl of ready-to-use antiserum. USP44 (ubiquitin specific peptidase 44) is a cysteine protease that edits ubiquitin chains on centromeric substrates, and it is best known for restraining the spindle assembly checkpoint so that chromosome segregation proceeds only after correct microtubule-kinetochore attachment. Loss or silencing of USP44 has been documented in B-cell lymphomas and in several solid tumor types, where reduced expression correlates with centrosome amplification and chromosomal instability, making the protein a recurrent marker in oncology and cell division research.

The antibody has been validated for Western blot and ELISA on human samples. Researchers studying mitotic fidelity, aneuploidy, Hodgkin lymphoma biology, and the broader deubiquitinase landscape typically pair this reagent with chromatin fractionation, immunoprecipitation of APC/C substrates, or quantitative ELISA of recombinant USP44. The unconjugated format leaves primary amines and cysteine residues free for downstream fluorescent or HRP labelling in custom assay development, and the rabbit host provides a robust secondary antibody selection for both immunoblotting and immunohistochemistry workflows.