Anti-USP21 Antibody

Raised in rabbit and supplied unconjugated, this polyclonal IgG reagent from Antibodies.com detects USP21, a cysteine-type deubiquitinating enzyme that belongs to the ubiquitin-specific protease family. The vial contains 200 µl of antibody, validated for Western blot and immunohistochemistry on human and mouse specimens.

USP21 catalyzes removal of ubiquitin from substrate proteins and has been linked in published studies to regulation of histone H2A monoubiquitination, modulation of STING-driven innate immune signaling, and stabilization of oncogenic transcription factors. Investigators deploy this reagent to map DUB activity in tumor lysates and characterize USP21 expression across normal versus diseased tissue panels.

The polyclonal format recognizes multiple epitopes across USP21, supporting detection of full-length protein and variant isoforms in lysates or fixed sections. Aliquoting upon receipt and storing refrigerated helps minimize freeze-thaw cycles and preserve binding activity through repeated blotting and staining experiments.