Anti-USP2 Antibody

USP2 (Ubiquitin Specific Peptidase 2) is a cysteine protease within the deubiquitinating enzyme (DUB) family that cleaves ubiquitin from substrate proteins, regulating their turnover, subcellular localization, and signaling output. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com detects endogenous USP2 in Western blot and immunohistochemistry workflows, with validated reactivity on human and rat specimens. Each vial supplies 100 µL of affinity-purified antibody suitable for probing cell lysates, tissue homogenates, and formalin-fixed paraffin-embedded sections used to characterize circadian rhythm regulation, apoptotic control, and tumor cell proliferation pathways. USP2 has been implicated in prostate cancer progression, breast cancer models, and hepatic lipid metabolism, making this reagent useful for studies of substrate deubiquitination, MDM2-p53 axis modulation, and epithelial sodium channel regulation. Polyclonal recognition provides coverage of multiple epitopes across the USP2 sequence, supporting reproducible signal across blot and slide-based assays. For best results, aliquot on receipt and store at -20 degrees C, avoiding repeated freeze-thaw cycles to preserve binding activity; HRP- or fluorophore-conjugated secondary antibodies can be selected to match the chosen detection modality.