Anti-USP16 Antibody

USP16 is a ubiquitin-specific cysteine protease that functions as a deubiquitinating enzyme (DUB), removing ubiquitin moieties from histone H2A to regulate chromatin remodeling, gene transcription, and cell cycle progression through the G2/M checkpoint. This unconjugated rabbit polyclonal IgG antibody from Antibodies.com is raised against human USP16 and is validated for western blot (WB) detection across human, mouse, and rat samples, supporting studies in DNA damage response, hematopoietic stem cell biology, and oncology research where USP16 activity has been linked to leukemia and solid tumor contexts. Supplied as 100 µL of antibody, the reagent supports multiple blot incubations and accommodates titration across lysate concentrations. The polyclonal format increases the likelihood of recognizing multiple epitopes on the ~93 kDa target, useful when probing post-translational modifications or splice variants. Researchers working on chromosome 21-linked pathways, including Down syndrome-associated phenotypes and dosage-sensitive transcriptional programs, rely on USP16 antibodies to track expression in cell-based and tissue-derived samples.