Anti-USP12 Antibody

This Rabbit polyclonal IgG reagent from Antibodies.com targets USP12 (Ubiquitin Specific Peptidase 12), a cysteine protease belonging to the ubiquitin-specific protease family. USP12 acts as a deubiquitinating enzyme that cleaves ubiquitin from substrate proteins and has documented roles in modulating histone H2A and H2B ubiquitination, regulating androgen receptor signaling, and supporting the DNA damage response through its interaction with the UAF1 and WDR20 activator complex. The unconjugated antibody is supplied as a 200 µl liquid aliquot and is validated for western blot detection of the human target. Polyclonal reactivity raised against conserved regions of the deubiquitinase enables consistent recognition of endogenous USP12 in standard immunoblotting workflows. Researchers investigating deubiquitinase activity, chromatin modification, or receptor turnover in human cell models can deploy this reagent with whole-cell lysate preparations separated by SDS-PAGE, followed by chemiluminescent detection. The IgG isotype allows straightforward pairing with anti-rabbit secondary antibodies in conventional western blot protocols, and the unconjugated format leaves open the option of custom fluorophore or enzyme labeling for users who require it.