Anti-USP1 Antibody

USP1 (Ubiquitin-Specific Protease 1) is a deubiquitinating enzyme central to the DNA damage response, where it removes ubiquitin marks from PCNA and FANCD2 to coordinate the Fanconi anemia repair pathway. This unconjugated rabbit polyclonal IgG reagent from Antibodies.com is affinity-purified against human USP1 and validated for Western Blot, supplied as a 200 µl liquid aliquot suitable for multiple immunoblot experiments. The polyclonal format recognizes several epitopes on the full-length protein, giving consistent band detection on lysates prepared in standard RIPA buffer from cultured human cell lines and tumor tissue. Investigators working on genome stability, BRCA-deficient cancer models, and DNA replication stress use USP1 immunoblots to monitor expression changes after genotoxic treatments and to confirm knockdown or overexpression in engineered cell lines. For best results, store at -20°C in small working aliquots and limit freeze-thaw cycles to preserve antibody activity.