Anti-Urotensin II Antibody

The Antibodies.com Anti-Urotensin II Antibody is a rabbit polyclonal reagent raised against the cyclic vasoactive peptide Urotensin II (UTS2), widely investigated for its role as one of the most potent endogenous vasoconstrictors characterized in mammals. The antibody is supplied as 100 µl of liquid formulation at 1 mg/ml in PBS containing 0.1% sodium azide and 50% glycerol, a cryoprotective buffer that allows storage at -20°C with minimal freeze-thaw damage to the immunoglobulin fraction.

Suitable for Western blot (WB) and immunohistochemistry (IHC), the unconjugated IgG fraction detects both the precursor prepro-Urotensin II and the mature cyclic peptide in human and mouse tissue sections and lysates. Urotensin II is studied in cardiovascular and renal pathophysiology, including hypertension, heart failure, diabetic nephropathy, and pulmonary hypertension, where altered UTS2/UT receptor signaling has been documented in vascular smooth muscle, cardiomyocytes, adrenal medulla, kidney tubules, and specific neuronal populations of the brainstem and spinal cord.

Researchers using this Antibodies.com polyclonal antibody commonly pair it with peptide-block controls to confirm signal specificity, since the peptide shares homology motifs with somatostatin-family ligands. The reagent is intended for research use only and should be handled with standard laboratory precautions due to the sodium azide preservative.