Anti-URI1 Antibody

This rabbit polyclonal IgG antibody from Antibodies.com targets URI1, an unconventional prefoldin RPB5-interactor that participates in the prefoldin-like complex and is implicated in transcriptional regulation through its interaction with RPB5, a shared subunit of RNA polymerases. URI1 has been described as a regulator of nutrient-sensing pathways, with links to mTORC1 signaling and to gene expression changes tied to cellular growth, and altered URI1 expression has been reported in several cancer types. The reagent is supplied as an unconjugated antiserum at 200 µl and is validated for Western blot detection of the human URI1 protein, supporting studies of transcription machinery biology, prefoldin complex function, and signaling downstream of nutrient status.