Anti-UPF2 Antibody

This rabbit polyclonal antibody targets UPF2, the central scaffold component of the nonsense-mediated mRNA decay (NMD) surveillance pathway and a required cofactor for Staufen-mediated mRNA decay (SMD). Supplied by Antibodies.com, the reagent is validated for Western blot (WB) and immunohistochemistry (IHC) applications across human, mouse, and rat samples. The unconjugated IgG is provided as 100 µl of a 1 mg/ml stock in PBS with 0.1% Sodium Azide and 50% glycerol, supporting direct labeling or use in standard chromogenic and chemiluminescent workflows. UPF2 acts as a bridging factor that recruits UPF1 to the surveillance complex via its interaction with UPF3B, and researchers commonly use this reagent to study transcript quality control, mRNA turnover, and translation termination fidelity in cell lysates and tissue sections.