Anti-UNC13D Antibody

UNC13D (also known as Munc13-4) is a Rab27a effector critical for cytotoxic granule docking and fusion in cytotoxic T lymphocytes and natural killer cells. Loss-of-function mutations in this gene cause familial hemophagocytic lymphohistiocytosis type 3 (FHL3), an autosomal recessive hyperinflammatory immunodeficiency. This rabbit polyclonal reagent from Antibodies.com targets UNC13D for western blot, immunohistochemistry, and immunofluorescence workflows on human samples. It is supplied as 100 µl of unconjugated antiserum, suitable for probing endogenous protein levels in lymphoid tissues, patient-derived lymphoblast cell lines, and primary NK cell cultures. The polyclonal format increases the likelihood of recognizing multiple epitopes of this approximately 123 kDa vesicle-priming factor, which is useful when characterizing novel FHL3-causing variants or monitoring granule release competence in cytotoxic lymphocyte assays.