Anti-UIMC1 Antibody

The Antibodies.com polyclonal antibody reagent targets UIMC1 (Ubiquitin Interaction Motif Containing 1), a 719-amino-acid scaffold protein also known as RAP80 that operates in the DNA damage response. This unconjugated, rabbit-hosted IgG preparation is validated for Western blot and immunofluorescence workflows and binds specifically to the human target, supporting research into BRCA1-A complex assembly at K63-linked ubiquitin chains flanking double-strand break lesions.

Supplied as 100 µl of liquid antiserum, the reagent is intended for use on cell lysate and fixed-cell sample preparations, allowing researchers to probe endogenous UIMC1 distribution in nuclear foci and chromatin-associated fractions. Its polyclonal format broadens epitope coverage across the UIM domains and coiled-coil regions, which is useful when studying post-translational modifications or isoform-specific interactions linked to genotoxic stress.

Within the Primary Antibodies category, this reagent fits into laboratory studies of homologous recombination, checkpoint signaling, and tumor suppressor pathways associated with BRCA1 function, and is supplied for research use only.