Anti-UGT1A6 Antibody

Polyclonal antibody raised in rabbit against the UDP-glucuronosyltransferase 1A6 enzyme, a phase II conjugation enzyme that catalyzes the transfer of glucuronic acid from UDP-glucuronic acid to small planar phenolic substrates, therapeutic drugs, and dietary xenobiotics. This unconjugated reagent from Antibodies.com is supplied as 100 µl of antiserum and is validated for Western blot detection of the human UGT1A6 protein, as well as for immunohistochemistry on fixed tissue sections, where it produces cytoplasmic staining characteristic of hepatocytes and gastrointestinal epithelial cells. The reagent was raised against a human UGT1A6 immunogen and is reactive with the human target, supporting studies of hepatic xenobiotic clearance, glucuronidation of phenolic compounds including serotonin, polymorphic variants of the UGT1A6 locus linked to inter-individual variation in drug metabolism, and altered UGT1A6 expression in pathological tissue samples. Researchers apply it to characterize drug-metabolizing capacity in cultured cell and tissue models, to monitor induction or suppression of this enzyme under pharmacological or environmental exposure, and to map UGT1A6 distribution across patient-derived specimens. The unconjugated format allows flexible downstream conjugation to HRP, fluorophores, or biotin in custom detection workflows.