Anti-UGT1A1 Antibody

This unconjugated rabbit polyclonal antibody targets UDP-glucuronosyltransferase 1A1 (UGT1A1), the hepatic phase II enzyme responsible for bilirubin conjugation and a key mediator of xenobiotic clearance. Supplied by Antibodies.com as a 100 µl aliquot at 1 mg/ml in PBS with 0.1% sodium azide and 50% glycerol, the reagent is validated for western blot, immunohistochemistry, and immunofluorescence workflows on human tissue. Researchers investigating Crigler-Najjar syndrome, Gilbert's syndrome, neonatal hyperbilirubinemia, and irinotecan-induced toxicity depend on UGT1A1 profiling in liver biopsies and hepatocyte models to characterize glucuronidation capacity. The polyclonal format broadens epitope coverage across the conserved carboxy-terminal region, supporting reproducible signal in paraffin-embedded sections and whole-cell lysates where monoclonal reagents may miss conformational variants. For short-term use, keep the vial refrigerated at 4°C; for extended storage, freeze at -20°C in single-use aliquots to limit freeze-thaw cycles and preserve antibody integrity. Sodium azide in the buffer provides antimicrobial protection, and the unconjugated format allows direct conjugation to fluorophores or HRP for customized detection assays.