Anti-UGT1A Antibody

UGT1A enzymes belong to the UDP-glucuronosyltransferase family, a group of phase II conjugation enzymes that attach glucuronic acid to substrates including bilirubin, steroid hormones, phenolic drugs, and environmental xenobiotics. This unconjugated rabbit polyclonal reagent from Antibodies.com targets UGT1A in human samples and is supplied as a 100 µl aliquot, validated for western blot and immunohistochemistry workflows.

The polyclonal antibody is raised in rabbit and detects the UGT1A protein in denaturing and fixed preparations, supporting studies of glucuronidation capacity in hepatic and intestinal tissue. Because UGT1A isoforms clear bilirubin and metabolize irinotecan, statins, and many phenolic compounds, the reagent is useful for research on drug clearance, neonatal jaundice, Crigler-Najjar syndrome, and Gilbert syndrome.

Researchers commonly apply this reagent to characterize UGT1A levels in liver biopsies, tumor specimens, and cell line panels when assessing detoxification capacity. Storage should follow standard antibody handling, with the unconjugated format allowing flexible detection chemistry through HRP or fluorescent secondary reagents.