Anti-UFD1L Antibody

Raised in rabbit and supplied as an unconjugated polyclonal reagent in a 100 µl vial, this Antibodies.com anti-UFD1L antibody is validated for western blot, immunohistochemistry, and immunofluorescence applications on human specimens. UFD1L encodes a subunit of the p97/VCP–UFD1L–NPL4 dislocase complex that retrotranslocates misfolded substrates from the endoplasmic reticulum to the cytosol for ubiquitin-proteasome degradation, and it also participates in DNA replication, cell-cycle progression, and the clearance of ubiquitinated proteins from the nucleus. Because the gene maps within the 22q11.2 DiGeorge syndrome critical region, this reagent is frequently used to investigate congenital heart defect and velocardiofacial syndrome models, alongside studies of ER-associated degradation and p97-dependent unfolding pathways. The polyclonal format broadens epitope coverage on UFD1L, supporting detection of isoform-specific expression patterns and post-translational modifications in fixed cells and tissue sections. Store refrigerated and protect from light; aliquot upon receipt to minimize freeze-thaw cycles and preserve antibody activity for repeat experiments.