Anti-UCHL5 Antibody

Targeting the C-terminal hydrolase UCHL5, this unconjugated polyclonal reagent from Antibodies.com recognizes the human protein in Western blot and immunohistochemistry applications. Supplied as 100 µL of rabbit antiserum, the antibody is intended for researchers investigating deubiquitinase activity, proteasome-dependent protein turnover, and chromatin-associated signaling.

UCHL5 (also known as UCH37) operates within the 19S regulatory particle of the proteasome, where it trims ubiquitin chains from substrates prior to degradation, and it is additionally recruited to the INO80 chromatin-remodeling complex. Published work links UCHL5 to TGF-β signaling and to altered expression in multiple cancers, where small-molecule DUB inhibitors such as b-AP15 are used as chemical probes.

Recommended storage is at -20 °C in working aliquots to limit freeze-thaw cycles and preserve performance across experiments. Reactivity with human UCHL5 has been verified by the manufacturer, while cross-reactivity with other species has not been formally characterized.