Anti-UCHL5 Antibody

Raised in rabbit, this unconjugated IgG polyclonal reagent from Antibodies.com targets UCHL5 (ubiquitin C-terminal hydrolase L5), a cysteine-type deubiquitinating enzyme that associates with the 26S proteasome and trims ubiquitin chains from substrates entering proteasomal degradation. The antibody is supplied as a 200 µl liquid aliquot and is validated for western blot, immunohistochemistry, immunoprecipitation, and flow cytometry on human and rat samples, giving laboratories a single reagent for tracking endogenous UCHL5 expression across multiple readouts.

UCHL5 (also called UCH37) functions within the ubiquitin-proteasome pathway, where it contributes to substrate deubiquitination at the proteasome lid, and is investigated in studies of proteasome biology, TGF-β signaling, DNA damage response, and tumor cell survival. Researchers examining proteasome dynamics, neurodegenerative disease models, or cancer pathways frequently use anti-UCHL5 antibodies to assess enzyme levels, monitor proteasome-associated DUB activity, or pull down interacting partners by IP. The polyclonal format yields recognition of multiple epitopes, supporting consistent detection across denaturing and native conditions.

As a research-use-only primary antibody, the reagent is intended for laboratory investigation rather than diagnostic or therapeutic use. Aliquoting upon receipt helps preserve activity across multiple experiments, and storage at the temperature indicated on the accompanying data sheet keeps the polyclonal population stable for routine western blot and immunoprecipitation workflows over extended studies.