Anti-Ubr1 Antibody

This polyclonal antibody from Antibodies.com targets Ubr1, a key E3 ubiquitin ligase that recognizes destabilizing N-terminal residues as part of the N-end rule proteolytic pathway. The reagent is raised in rabbit and supplied as 100 µl of unconjugated antiserum for western blot, immunohistochemistry, and ELISA workflows. It is validated for reactivity against human and mouse samples, supporting studies in cell signaling and its relevance to Johanson-Blizzard syndrome, where loss-of-function mutations in the Ubr1 gene disrupt exocrine pancreatic development and other tissues. Researchers investigating proteostasis, substrate recognition by N-recognins, and the broader ubiquitin-proteasome system will find this reagent useful for probing endogenous protein levels across cell lines and tissue sections.