Anti-UBP1 Antibody

A rabbit polyclonal IgG reagent from Antibodies.com raised against Upstream Binding Protein 1 (UBP1), supplied unconjugated in a 50 µl vial and validated for western blot detection of human samples. UBP1, also known as LBP-1a/LBP-1b, maps to chromosome 3p22.3 and encodes splice variants with apparent molecular masses of roughly 63–68 kDa that localize to the nucleoplasm and cytosol, where they assemble into heteromeric DNA-binding complexes with the related CP2-family factors TFCP2 and TFCP2L1.

This Antibodies.com antibody supports investigations into UBP1's role in hypoxia-responsive transcriptional programs, including its crosstalk with HIF-1α, as well as its regulation of the P450scc promoter in steroidogenic cell models such as JEG-3, NCI-H295A, HeLa, and HepG2. The unconjugated IgG format lets investigators pair it with HRP, biotin, or fluorophore-conjugated secondaries of their choice on nitrocellulose or PVDF membranes, making it flexible for chemiluminescent and fluorescent detection platforms. Vials are shipped frozen; store at -20 °C and avoid repeated freeze-thaw cycles by aliquoting on first thaw to preserve antibody activity. Intended for research use only.