Anti-Ubiquilin-1 Antibody

This rabbit polyclonal antibody from Antibodies.com targets Ubiquilin-1 (UBQLN1), a ubiquitin-like shuttle protein that delivers polyubiquitinated substrates to the proteasome for degradation. Ubiquilin-1 plays a central role in protein quality control and has been studied in the context of neurodegeneration, including Alzheimer's disease, where altered expression and proteasomal dysfunction have been reported.

The unconjugated reagent is supplied as 100 µl of polyclonal antiserum and is validated for Western blot and immunofluorescence on human samples. Researchers investigating the ubiquitin-proteasome system, ER-associated degradation, and autophagy pathways commonly use UBQLN1 antibodies to examine substrate recognition, proteasomal targeting, and aggregate clearance in cellular models. The polyclonal format provides recognition of multiple epitopes on the target protein, supporting reproducible detection across experimental conditions.