Anti-UBE3C Antibody

This polyclonal rabbit IgG antibody targets UBE3C (Ubiquitin Protein Ligase E3C), an E3 ubiquitin ligase containing a HECT catalytic domain that mediates polyubiquitination of substrate proteins destined for proteasomal degradation. Produced by Antibodies.com, the reagent is supplied as 100 µl of unconjugated antiserum and is validated for Western blot (WB), immunohistochemistry (IHC), and immunofluorescence (IF) workflows on human samples and cells. The antibody recognizes endogenous UBE3C, enabling researchers to monitor expression of this HECT-domain ligase in studies of the ubiquitin-proteasome system, ER-associated degradation (ERAD), and related protein quality control pathways. As a polyclonal reagent, it offers broader epitope coverage than a monoclonal, and the unconjugated format allows users to couple it to their preferred fluorophore or enzyme for custom detection chemistries. For long-term storage, keep the vial refrigerated and avoid repeated freeze-thaw cycles by preparing working aliquots. Intended for research use only.