Anti-UBE2W Antibody

This rabbit polyclonal antibody from Antibodies.com targets UBE2W, a ubiquitin-conjugating enzyme (E2) that participates in protein ubiquitination through an unusual mechanism, initiating ubiquitin transfer onto N-terminal residues of substrate proteins rather than internal lysine residues. The unconjugated IgG reagent is supplied at 100 µl and is validated for western blot (WB) and immunohistochemistry (IHC) workflows on human and mouse samples.

UBE2W has been characterized for its role in the DNA damage response, including functional interactions with PCNA during monoubiquitination and contributions to BRCA1-associated genome stability pathways. Researchers studying post-translational modification, chromatin-associated ubiquitin signaling, or cancer biology use this reagent to probe endogenous UBE2W expression across cell lines and tissue sections.

The polyclonal host response provides broader epitope coverage than monoclonal alternatives, supporting detection of multiple isoforms of the enzyme. Aliquot the reagent upon first use and store refrigerated; avoid repeated freeze-thaw cycles to preserve binding activity.